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YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches.

ABSTRACT: Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and highlight open questions. YAP/TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therapeutic efficacy, and here we give an overview of the current treatment strategies and pioneering clinical trials.

SUBMITTER: Piccolo S 

PROVIDER: S-EPMC7614914 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches.

Piccolo Stefano S   Panciera Tito T   Contessotto Paolo P   Cordenonsi Michelangelo M  

Nature cancer 20221223 1

Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ) in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ biology, their regulation by Hippo signaling and mechanotransduction and highlight open questions. YAP/TAZ signaling is an addiction shared by multiple tumor types and their microenvironments, providing many malignant attributes. As such, it represents an important vulnerability that may offer a broad window of therap  ...[more]