Maternal γδ T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner.

ABSTRACT: Immune development is profoundly influenced by vertically transferred cues. However, little is known about how maternal innate-like lymphocytes regulate offspring immunity. Here, we show that mice born from γδ T cell-deficient (TCRδ^-/-) dams display an increase in first-breath-induced inflammation, with a pulmonary milieu selectively enriched in type 2 cytokines and type 2-polarized immune cells, when compared with the progeny of γδ T cell-sufficient dams. Upon helminth infection, mice born from TCRδ^-/- dams sustain an increased type 2 inflammatory response. This is independent of the genotype of the pups. Instead, the offspring of TCRδ^-/- dams harbors a distinct intestinal microbiota, acquired during birth and fostering, and decreased levels of intestinal

SUBMITTER: Papotto PH 

PROVIDER: S-EPMC7615642 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature