Dataset Information

Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults.

ABSTRACT:

Background & aims

Evidence is sparse and inconclusive on the association between long-term fine (≤2.5 μm) particulate matter (PM_2.5) exposure and esophageal cancer. We aimed to assess the association of PM_2.5 with esophageal cancer risk and compared the esophageal cancer risk attributable to PM_2.5 exposure and other established risk factors.

Methods

This study included 510,125 participants without esophageal cancer at baseline from China Kadoorie Biobank. A high-resolution (1 × 1 km) satellite-based model was used to estimate PM_2.5 exposure during the study period. Hazard ratios (HR) and 95% CIs of PM_2.5 with esophageal cancer incidence were estimated using Cox proportional hazard model. Population attributable fractions for PM_2.5 and other established risk factors were estimated.

Results

There was a linear concentration-response relationship between long-term PM_2.5 exposure and esophageal cancer. For each 10-μg/m³ increase in PM_2.5, the HR was 1.16 (95% CI, 1.04-1.30) for esophageal cancer incidence. Compared with the first quarter of PM_2.5 exposure, participants in the highest quarter had a 1.32-fold higher risk for esophageal cancer, with an HR of 1.32 (95% CI, 1.01-1.72). The population attributable risk because of annual average PM_2.5 concentration ≥35 μg/m³ was 23.3% (95% CI, 6.6%-40.0%), higher than the risks attributable to lifestyle risk factors.

Conclusions

This large prospective cohort study of Chinese adults found that long-term exposure to PM_2.5 was associated with an elevated risk of esophageal cancer. With stringent air pollution mitigation measures in China, a large reduction in the esophageal cancer disease burden can be expected.

SUBMITTER: Sun D

PROVIDER: S-EPMC7615725 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Publications

Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults.

Sun Dong D Liu Cong C Zhu Yunqing Y Yu Canqing C Guo Yu Y Sun Dianjianyi D Pang Yuanjie Y Pei Pei P Du Huaidong H Yang Ling L Chen Yiping Y Meng Xia X Liu Yang Y Zhang Jun J Schmidt Dan D Avery Daniel D Chen Junshi J Chen Zhengming Z Lv Jun J Kan Haidong H Li Liming L

Gastroenterology 20230413 1

<h4>Background & aims</h4>Evidence is sparse and inconclusive on the association between long-term fine (≤2.5 μm) particulate matter (PM<sub>2.5</sub>) exposure and esophageal cancer. We aimed to assess the association of PM<sub>2.5</sub> with esophageal cancer risk and compared the esophageal cancer risk attributable to PM<sub>2.5</sub> exposure and other established risk factors.<h4>Methods</h4>This study included 510,125 participants without esophageal cancer at baseline from China Kadoorie B ...[more]

PMID: 37059339

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Project description:BackgroundPrevious research has identified an association between fine particulate matter (PM2.5) air pollution and lung cancer. Most of the evidence for this association, however, is based on research using lung cancer mortality, not incidence. Research that examines potential associations between PM2.5 and incidence of non-lung cancers is limited.ObjectivesThe primary purpose of this study was to evaluate the association between the incidence of cancer and exposure to PM2.5 using >8.5 million cases of cancer incidences from U.S. registries. Secondary objectives include evaluating the sensitivity of the associations to model selection, spatial control, and latency period as well as estimating the exposure-response relationship for several cancer types.MethodsSurveillance, Epidemiology, and End Results (SEER) program data were used to calculate incidence rates for various cancer types in 607 U.S. counties. County-level PM2.5 concentrations were estimated using integrated empirical geographic regression models. Flexible semi-nonparametric regression models were used to estimate associations between PM2.5 and cancer incidence for selected cancers while controlling for important county-level covariates. Primary time-independent models using average incidence rates from 1992-2016 and average PM2.5 from 1988-2015 were estimated. In addition, time-varying models using annual incidence rates from 2002-2011 and lagged moving averages of annual estimates for PM2.5 were also estimated.ResultsThe incidences of all cancer and lung cancer were consistently associated with PM2.5. The incident rate ratios (IRRs), per 10-μg/m3 increase in PM2.5, for all and lung cancer were 1.09 (95% CI: 1.03, 1.14) and 1.19 (95% CI: 1.09, 1.30), respectively. Less robust associations were observed with oral, rectal, liver, skin, breast, and kidney cancers.DiscussionExposure to PM2.5 air pollution contributes to lung cancer incidence and is potentially associated with non-lung cancer incidence. https://doi.org/10.1289/EHP7246.

Dataset Information

Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults.

Background & aims

Methods

Results

Conclusions

Publications

Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults.

Similar Datasets

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