Collagenase Injection versus Limited Fasciectomy for Dupuytren's Contracture.

ABSTRACT:

Background

Treatments for Dupuytren's contracture include limited fasciectomy and collagenase injection. Comparisons of the effectiveness of these treatments have been limited.

Methods

We performed an unblinded, multicenter, pragmatic, two-group, randomized, controlled noninferiority trial comparing collagenase injection with limited fasciectomy in persons with moderate Dupuytren's contracture. The primary outcome was the score on the Patient Evaluation Measure-Hand Health Profile (PEM), a questionnaire for assessing hand health as reported by the patient, at 1 year after treatment. Scores on the PEM range from 0 to 100, with higher scores indicating worse outcomes. The prespecified noninferiority margin was 6 points.

Results

A total of 672 persons (336 per group) wer

SUBMITTER: Dias J 

PROVIDER: S-EPMC7616701 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature