Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study.

ABSTRACT:

Background

A Zika virus epidemic emerged in northeast Brazil in 2015 and was followed by a striking increase in congenital microcephaly cases, triggering a declaration of an international public health emergency. This is the final report of the first case-control study evaluating the potential causes of microcephaly: congenital Zika virus infection, vaccines, and larvicides. The published preliminary report suggested a strong association between microcephaly and congenital Zika virus infection.

Methods

We did a case-control study in eight public maternity hospitals in Recife, Brazil. Cases were neonates born with microcephaly, defined as a head circumference of 2 SD below the mean. Two controls without microcephaly were matched to each case by expected date of delivery and a

SUBMITTER: de Araujo TVB 

PROVIDER: S-EPMC7617036 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature