In vivo diffusion MRI of the human heart using a 300 mT/m gradient system.

ABSTRACT:

Purpose

This work reports for the first time on the implementation and application of cardiac diffusion-weighted MRI on a Connectom MR scanner with a maximum gradient strength of 300 mT/m. It evaluates the benefits of the increased gradient performance for the investigation of the myocardial microstructure.

Methods

Cardiac diffusion-weighted imaging (DWI) experiments were performed on 10 healthy volunteers using a spin-echo sequence with up to second- and third-order motion compensation ( M2$$ {M}_2 $$ and M3$$ {M}_3 $$ ) and b=100, 450$$ b=100,450 $$ , and 1000 s/mm2$$ \mathrm{s}/\mathrm{m}{\mathrm{m}}^2 $$ (twice the bmax$$ {b}_{\mathrm{max}} $$ commonly used on clinical scanners). Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and secondary eigenvect

SUBMITTER: Afzali M 

PROVIDER: S-EPMC7617480 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature