Associations Between Snoring, Body Mass Index and Coronary Artery Diseases: Observational and Mendelian Randomization Study in Asia.

ABSTRACT:

Background and objective

Previous observational studies reported a complex relationship between snoring and coronary artery disease (CAD). We aimed to estimate the causal associations between snoring and CAD among East Asian people, and the effects independent of BMI.

Methods

Based on 497,250 adults from China Kadoorie Biobank (CKB), we performed a conventional prospective analysis between snoring and CAD outcomes, using the multivariable Cox regression. We also leveraged genome-wide association (GWAS) summary statistics of snoring and BMI from CKB (n = 100,626, 47,208 snorers) and CAD outcomes from Biobank of Japan (BBJ, 5891-25,892 cases, 142,336-168,186 controls). Single-variable and multivariable two-sample bi-directional Mendelian randomization (MR) analyses were perfor

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC7617645 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature