Ontology highlight
ABSTRACT:
SUBMITTER: Cassandras M
PROVIDER: S-EPMC7642162 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Cassandras Monica M Wang Chaoqun C Kathiriya Jaymin J Tsukui Tatsuya T Matatia Peri P Matthay Michael M Wolters Paul P Molofsky Ari A Sheppard Dean D Chapman Hal H Peng Tien T
Nature cell biology 20201012 11
Aberrant epithelial reprogramming can induce metaplastic differentiation at sites of tissue injury that culminates in transformed barriers composed of scar and metaplastic epithelium. While the plasticity of epithelial stem cells is well characterized, the identity and role of the niche has not been delineated in metaplasia. Here, we show that Gli1<sup>+</sup> mesenchymal stromal cells (MSCs), previously shown to contribute to myofibroblasts during scarring, promote metaplastic differentiation o ...[more]