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Co-Catalyzed Transannulation of Pyridotriazoles with Isothiocyanates and Xanthate Esters.

ABSTRACT: An efficient radical transannulation reaction of pyridotriazoles with isothiocyanates and xanthate esters was developed. This method features conversion of pyridotriazoles into two N-fused heterocyclic aromatic systems-imino-thiazolopyridines and oxo-thiazolopyridine derivatives-via one-step Co(II)-catalyzed transannulation reaction proceeding via a radical mechanism. The synthetic usefulness of the developed method was illustrated in the synthesis of amino acid derivatives and further transformations of obtained reaction products.

SUBMITTER: Zhang Z

PROVIDER: S-EPMC7655727 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Co-Catalyzed Transannulation of Pyridotriazoles with Isothiocyanates and Xanthate Esters.

Zhang Ziyan Z Gevorgyan Vladimir V

Organic letters 20201012 21

An efficient radical transannulation reaction of pyridotriazoles with isothiocyanates and xanthate esters was developed. This method features conversion of pyridotriazoles into two <i>N</i>-fused heterocyclic aromatic systems-imino-thiazolopyridines and oxo-thiazolopyridine derivatives-via one-step Co(II)-catalyzed transannulation reaction proceeding via a radical mechanism. The synthetic usefulness of the developed method was illustrated in the synthesis of amino acid derivatives and further tr ...[more]

PMID: 33044833

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