Integrated Co-functional Network Analysis on the Resistance and Virulence Features in Acinetobacter baumannii.

ABSTRACT: Acinetobacter baumannii is one of the most troublesome bacterial pathogens that pose major public health threats due to its rapidly increasing drug resistance property. It is not only derived from clinic setting but also emerges from aquaculture as a fish pathogen, which could pass the resistant genes in the food chain. Understanding the mechanism of antibiotic resistance development and pathogenesis will aid our battle with the infections caused by A. baumannii. In this study, we constructed a co-functional network by integrating multiple sources of data from A. baumannii and then used the k-shell decomposition to analyze the co-functional network. We found that genes involving in basic cellular physiological function, including genes for antibiotic resistance, tended

SUBMITTER: Xie R 

PROVIDER: S-EPMC7667040 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature