Patterns of multimorbidity and their effects on adverse outcomes in rheumatoid arthritis: a study of 5658 UK Biobank participants.

ABSTRACT:

Objective

To investigate how the type and number of long-term conditions (LTCs) impact on all-cause mortality and major adverse cardiovascular events (MACE) in people with rheumatoid arthritis (RA).

Design

Population-based longitudinal cohort study.

Setting

UK Biobank.

Participants

UK Biobank participants (n=502 533) aged between 37 and 73 years old.

Primary outcome measures

Primary outcome measures were risk of all-cause mortality and MACE.

Methods

We examined the relationship between LTC count and individual comorbid LTCs (n=42) on adverse clinical outcomes in participants with self-reported RA (n=5658). Risk of all-cause mortality and MACE were compared using Cox's proportional hazard models adjusted for lifestyle factors (smoking, alcohol inta

SUBMITTER: McQueenie R 

PROVIDER: S-EPMC7684828 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature