DNA methylation signatures to predict the cervicovaginal microbiome status.

ABSTRACT:

Background

The composition of the microbiome plays an important role in human health and disease. Whether there is a direct association between the cervicovaginal microbiome and the host's epigenome is largely unexplored.

Results

Here we analyzed a total of 448 cervicovaginal smear samples and studied both the DNA methylome of the host and the microbiome using the Illumina EPIC array and next-generation sequencing, respectively. We found that those CpGs that are hypo-methylated in samples with non-lactobacilli (O-type) dominating communities are strongly associated with gastrointestinal differentiation and that a signature consisting of 819 CpGs was able to discriminate lactobacilli-dominating (L-type) from O-type samples with an area under the receiver operator characterist

SUBMITTER: Nene NR 

PROVIDER: S-EPMC7686703 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature