Human levator veli palatini muscle: a novel source of mesenchymal stromal cells for use in the rehabilitation of patients with congenital craniofacial malformations.

ABSTRACT:

Background

Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation aimed at finding optimal sources of multipotent cells that can be isolated via non-invasive procedures. In this study, we analyzed whether levator veli palatini muscle fragments, which can be readily obtained in non-invasive manner during palatoplasty in cleft palate patients, represent a novel source of MSCs with osteogenic potential.

Methods

We obtained levator veli palatini muscle fragments (3-5 mm³), during surgical repair of cleft palate in 5 u

SUBMITTER: Bueno DF 

PROVIDER: S-EPMC7687766 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature