Ecological Structuring of Temperate Bacteriophages in the Inflammatory Bowel Disease-Affected Gut.

ABSTRACT: The aim of this study was to elucidate the ecological structure of the human gut temperate bacteriophage community and its role in inflammatory bowel disease (IBD). Temperate bacteriophages make up a large proportion of the human gut microbiota and are likely to play a role in IBD pathogenesis. However, many of these bacteriophages await characterization in reference databases. Therefore, we conducted a large-scale reconstruction of temperate bacteriophage and bacterial genomes from the whole-metagenome sequence data generated by the IBD Multi'omics Database project. By associating phages with their hosts via genome comparisons, we found that temperate bacteriophages infect a phylogenetically wide range of bacteria. The majority of variance in bacteriophage community composition was explai

SUBMITTER: Nishiyama H 

PROVIDER: S-EPMC7692956 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature