Somatic selection distinguishes oncogenes and tumor suppressor genes.

ABSTRACT:

Motivation

Functions of cancer driver genes vary substantially across tissues and organs. Distinguishing passenger genes, oncogenes (OGs) and tumor-suppressor genes (TSGs) for each cancer type is critical for understanding tumor biology and identifying clinically actionable targets. Although many computational tools are available to predict putative cancer driver genes, resources for context-aware classifications of OGs and TSGs are limited.

Results

We show that the direction and magnitude of somatic selection of protein-coding mutations are significantly different for passenger genes, OGs and TSGs. Based on these patterns, we develop a new method (genes under selection in tumors) to discover OGs and TSGs in a cancer-type specific manner. Genes under selection in tumors show

SUBMITTER: Chandrashekar P 

PROVIDER: S-EPMC7703750 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature