Exploring the Molecular Mechanism of Qing Guang An Granule in Treating Glaucoma Using Network Pharmacology and Molecular Docking.

ABSTRACT:

Background

Qing Guang An Granule (QGAG), a Chinese patent medicine, has been used clinically to treat glaucoma for more than 20 years.

Objective

To explore the possible mechanism of treatment of QGAG in glaucoma by using network pharmacology and molecular docking in this study.

Methods

Active compounds and targets of each herb in QGAG were retrieved via the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). Glaucoma-related targets were acquired from OMIM and DisGeNET database. Key targets of QGAG against glaucoma were acquired by overlapping the above targets via the Venn diagram. Using the DAVID, Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the key targets were pe

SUBMITTER: Ou C 

PROVIDER: S-EPMC7704137 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature