Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder.

ABSTRACT: Post-traumatic stress disorder (PTSD) impacts many veterans and active duty soldiers, but diagnosis can be problematic due to biases in self-disclosure of symptoms, stigma within military populations, and limitations identifying those at risk. Prior studies suggest that PTSD may be a systemic illness, affecting not just the brain, but the entire body. Therefore, disease signals likely span multiple biological domains, including genes, proteins, cells, tissues, and organism-level physiological changes. Identification of these signals could aid in diagnostics, treatment decision-making, and risk evaluation. In the search for PTSD diagnostic biomarkers, we ascertained over one million molecular, cellular, physiological, and clinical features from three cohorts of male veterans. In a discovery

SUBMITTER: Dean KR 

PROVIDER: S-EPMC7714692 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature