CD4 response of QuantiFERON-TB Gold Plus for positive consistency of latent tuberculosis infection in patients on dialysis.

ABSTRACT: A significantly negative reversion in the QuantiFERON-TB Gold In-tube (QFT-GIT) test is reported in patients on dialysis, which makes the results unreliable. The CD4 and CD8 responses of the QFT-Gold plus (QFT-Plus) may have better positive consistency, but this needs to be investigated. We enrolled dialysis patients with baseline positive QFT-GIT₀ results and conducted two rounds of follow-up paired QFT-GIT_1&2 and QFT-Plus_1&2 tests at an interval of 6 months. The positive consistency, concordance, and discordance of the QFT results were analyzed. A total of 236 patients on dialysis were screened, and 73 participants with positive QFT-GIT₀ results were enrolled. The baseline QFT-GIT₀ response was higher in the 1st QFT-Plus₁(

SUBMITTER: Wang PH 

PROVIDER: S-EPMC7721715 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature