Assessment of IL-7RA T244I Polymorphism as a Risk Factor of Multiple Sclerosis in Turkish Population.

ABSTRACT:

Introduction

The T244I variant of the IL-7RA gene, rs6897932, is one of the first polymorphisms found to be associated with the development of multiple sclerosis (MS). Although several studies provided evidence for the association of MS and this variant, other studies could not confirm this result. These inconsistent results suggest that the role of this polymorphism in the development of disease is associated with ethnicity.

Methods

We investigated rs6897932 polymorphisms in a large cohort of patients with MS and healthy controls in a turkish population.

Results

In our study, there were no significant differences in genotype frequencies in the IL-7RA rs6897932 polymorphism and no significant difference between C and T alleles in patients with MS and controls.

Conc

SUBMITTER: Unsal MA 

PROVIDER: S-EPMC7735144 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature