Dataset Information

Intrathecally produced CXCL13: A predictive biomarker in multiple sclerosis.

ABSTRACT:

Background

Clinicians caring for patients with Multiple Sclerosis (MS) need improved biomarkers to aid them in disease management.

Objective

We assessed the predictive value of the candidate biomarker CXCL13 index in comparison to oligoclonal bands (OCBs) and CSF neurofilament light (NfL) concentration, examining the ability of each biomarker to predict future disease activity in clinically and radiologically isolated syndromes, relapsing-remitting MS, and progressive MS.

Methods

Matched serum and CSF samples were obtained from 67 non-inflammatory neurologic disease patients and 67 MS patients. CSF and serum CXCL13 and CSF NfL were analyzed by Luminex and ELISA, respectively. CXCL13 data were also analyzed as CSF/serum ratios and indices. Electronic medical records were accessed to determine diagnosis, CSF profiles, and disease activity after the lumbar puncture.

Results

Among CXCL13 measures, CXCL13 index was the best predictor of future disease activity in MS patients (AUC = 0.82; CI = 0.69-0.95; p = 0.0002). CXCL13 index values were significantly elevated in activity-positive MS patients compared to activity-negative patients (p < 0.0001). As a single predictor, CXCL13 index outperformed both OCBs and CSF NfL in sensitivity, specificity, and positive and negative predictive value, for future disease activity in MS patients. Moreover, combining CXCL13 index and CSF NfL status improved sensitivity and predictive values for disease activity in MS patients.

Conclusions

The CXCL13 index is an excellent candidate prognostic biomarker for disease activity in patients with MS.

SUBMITTER: DiSano KD

PROVIDER: S-EPMC7747124 | biostudies-literature | 2020 Oct-Dec

REPOSITORIES: biostudies-literature

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Publications

Intrathecally produced CXCL13: A predictive biomarker in multiple sclerosis.

DiSano Krista D KD Gilli Francesca F Pachner Andrew R AR

Multiple sclerosis journal - experimental, translational and clinical 20201001 4

<h4>Background</h4>Clinicians caring for patients with Multiple Sclerosis (MS) need improved biomarkers to aid them in disease management.<h4>Objective</h4>We assessed the predictive value of the candidate biomarker CXCL13 index in comparison to oligoclonal bands (OCBs) and CSF neurofilament light (NfL) concentration, examining the ability of each biomarker to predict future disease activity in clinically and radiologically isolated syndromes, relapsing-remitting MS, and progressive MS.<h4>Metho ...[more]

PMID: 33403120

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Project description:BackgroundNeurofilament light chain (NfL) in cerebrospinal fluid (CSF) is a biomarker of multiple sclerosis (MS). However, CSF sampling is invasive and has limited the clinical application. With the development of highly sensitive single-molecule assay, the accurate quantification of the very low NfL levels in blood become feasible. As evidence being accumulated, we performed a meta-analysis to evaluate the diagnostic and predictive value of blood NfL in MS patients.MethodsWe performed literature search on PubMed, EMBASE, Web of Science and Cochrane Library from inception to May 31, 2022. The blood NfL differences between MS vs. controls, MS vs. clinically isolated syndrome (CIS), progressive MS (PMS) vs. relapsing-remitting MS (RRMS), and MS in relapse vs. MS in remission were estimated by standard mean difference (SMD) and corresponding 95% confidence interval (CI). Pooled hazard ratio (HR) and 95%CI were calculated to predict time to reach Expanded Disability Status Scale (EDSS) score≥4.0 and to relapse.ResultsA total of 28 studies comprising 6545 MS patients and 2477 controls were eligible for meta-analysis of diagnosis value, and 5 studies with 4444 patients were synthesized in analysis of predictive value. Blood NfL levels were significantly higher in MS patients vs. age-matched controls (SMD = 0.64, 95%CI 0.44-0.85, P<0.001), vs. non-matched controls (SMD = 0.76, 95%CI 0.56-0.96, P<0.001) and vs. CIS patients (SMD = 0.30, 95%CI 0.18-0.42, P<0.001), in PMS vs. RRMS (SMD = 0.56, 95%CI 0.27-0.85, P<0.001), and in relapsed patients vs. remitted patients (SMD = 0.54, 95%CI 0.16-0.92, P = 0.005). Patients with high blood NfL levels had shorter time to reach EDSS score≥4.0 (HR = 2.36, 95%CI 1.32-4.21, P = 0.004) but similar time to relapse (HR = 1.32, 95%CI 0.90-1.93, P = 0.155) compared to those with low NfL levels.ConclusionAs far as we know, this is the first meta-analysis evaluating the diagnosis and predictive value of blood NfL in MS. The present study indicates blood NfL may be a useful biomarker in diagnosing MS, distinguishing MS subtypes and predicting disease worsening in the future.

Dataset Information

Intrathecally produced CXCL13: A predictive biomarker in multiple sclerosis.

Background

Objective

Methods

Results

Conclusions

Publications

Intrathecally produced CXCL13: A predictive biomarker in multiple sclerosis.

Similar Datasets

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