Incidence and outcomes of radiation-induced late cranial neuropathy in 10-year survivors of head and neck cancer.

ABSTRACT:

Objectives

To characterize the late cranial neuropathy among 10-year survivors of head and neck cancer treatment.

Materials and methods

We retrospectively evaluated patients treated with curative-intent radiation for HNC between 1990 and 2005 at a single institution with systematic multidisciplinary follow-up ≥ 10 years. New findings of CNP were considered radiation-induced when examination, imaging and/or biopsy did not demonstrate a structural or malignant cause. Cox proportional hazards modeling was used for univariable analysis (UVA) and multivariable analysis (MVA) for time to CNP after completion of radiation.

Results

We identified 112 patients with no evidence of disease and follow-up ≥ 10 years (median 12.2). Sixteen (14%) patients developed at least one CNP.

SUBMITTER: Dong Y 

PROVIDER: S-EPMC7747216 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature