Antimicrobial prophylaxis administration after umbilical cord clamping in cesarean section and the risk of surgical site infection: a cohort study with 55,901 patients.

ABSTRACT:

Background

The World Health Organization (WHO) recommends administration of surgical antimicrobial prophylaxis (SAP) in cesarean section prior to incision to prevent surgical site infections (SSI). This study aimed to determine whether SAP administration following cord clamping confers an increased SSI risk to the mother.

Methods

Study design: Cohort.

Setting

75 participating Swiss hospitals, from 2009 to 2018.

Participants

A total of 55,901 patients were analyzed.

Main outcome measures

We assessed the association between SAP administration relative to incision and clamping and the SSI rate, using generalized linear multilevel models, adjusted for patient characteristics, procedural variables, and health-care system factors.

Results

SAP was admini

SUBMITTER: Sommerstein R 

PROVIDER: S-EPMC7754587 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature