Timing of Food Intake Drives the Circadian Rhythm of Blood Pressure.

ABSTRACT: Timing of food intake has become a critical factor in determining overall cardiometabolic health. We hypothesized that timing of food intake entrains circadian rhythms of blood pressure (BP) and renal excretion in mice. Male C57BL/6J mice were fed ad libitum or reverse feeding (RF) where food was available at all times of day or only available during the 12-h lights-on period, respectively. Mice eating ad libitum had a significantly higher mean arterial pressure (MAP) during lights-off compared to lights-on (113?±?2 mmHg vs 100?±?2 mmHg, respectively; P?P?Bmal1 knockout mice (Bmal1KO) underwent the same feeding protocol. As previously reported, Bmal1KO mice did not exhibit a diurnal MAP rhythm during ad libitum feeding (95?±?1 mmHg vs 92?±?3 mmHg, lights-off vs lights-on; P?>?0.05); however, RF induced a diurnal rhythm of MAP (79?±?3 mmHg vs 95?±?2 mmHg, lights-off vs lights-on phase; P?

SUBMITTER: Zhang D 

PROVIDER: S-EPMC7772288 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature