Essential Oil of Acorus tatarinowii Schott Ameliorates Aβ-Induced Toxicity in Caenorhabditis elegans through an Autophagy Pathway.

ABSTRACT:

Background

Acorus tatarinowii Schott [Shi Chang Pu in Chinese (SCP)] is a traditional Chinese medicine frequently used in the clinical treatment of dementia, amnesia, epilepsy, and other mental disorders. Previous studies have shown the potential efficacy of SCP against Alzheimer's disease (AD). Nevertheless, the active constituents and the modes of action of SCP in AD treatment have not been fully elucidated.

Purpose

The aim of this study was to investigate the protective effects of SCP on abnormal proteins and clarify its molecular mechanisms in the treatment of AD by using a Caenorhabditis elegans (C. elegans) model.

Methods

This study experimentally assessed the effect of SCP-Oil in CL4176 strains expressing human Aβ in muscle cells and

SUBMITTER: Chen XY 

PROVIDER: S-EPMC7773457 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature