Statin exposure and risk of cancer in people with and without HIV infection.

ABSTRACT:

Objective

To determine whether statin exposure is associated with decreased cancer and mortality risk among persons with HIV (PWH) and uninfected persons. Statins appear to have immunomodulatory and anti-inflammatory effects and may reduce cancer risk, particularly among PWH as they experience chronic inflammation and immune activation.

Design

Propensity score-matched cohort of statin-exposed and unexposed patients from 2002 to 2017 in the Veterans Aging Cohort Study (VACS), a large cohort with cancer registry linkage and detailed pharmacy data.

Methods

We calculated Cox regression hazard ratios (HRs) and 95% confidence intervals (CI) associated with statin use for all cancers, microbial cancers (associated with bacterial or oncovirus coinfection), nonmicrobial cancer

SUBMITTER: Bedimo RJ 

PROVIDER: S-EPMC7775280 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature