Early Urinary Metabolomics in Patent Ductus Arteriosus Anticipates the Fate: Preliminary Data.

ABSTRACT: Introduction: In premature neonates, the persistence of hemodynamically significant ductus arteriosus (hsPDA) can be associated with short- and long-term consequences, impairing their outcome. The correct strategy of management for such condition is under debate, especially regarding contraindications and/or side effects. In recent years, metabolomics was applied to several perinatal, pediatric, and adult conditions to investigate potential biomarkers of disease, which have become useful for early diagnosis and/or therapeutic management. Aim of the Study: The main purpose of our exploratory study was to asses, through ¹H-NMR metabolomics analysis of urinary samples at birth, possible metabolic pathways differentiating, with a significant predictive power, those pre

SUBMITTER: Bardanzellu F 

PROVIDER: S-EPMC7779766 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature