Integrated Morphoelectric and Transcriptomic Classification of Cortical GABAergic Cells.

ABSTRACT: Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 4,200 mouse visual cortical GABAergic interneurons and reconstructed the local morphologies of 517 of those neurons. We find that most transcriptomic types (t-types) occupy specific laminar positions within visual cortex, and, for most types, the cells mapping to a t-type exhibit consistent electrophysiological and morphological properties. These properties display both discrete and continuous variation among t-types. Through multimodal integrated analysis, we define 28 met-types that have congruent morphological, electrophysiologic

SUBMITTER: Gouwens NW 

PROVIDER: S-EPMC7781065 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature