Central location and risk of imaging occult mediastinal lymph node involvement in cN0T2-4 non-small cell lung cancer.

ABSTRACT:

Background

Appropriate pre-operative staging is a cornerstone in the treatment of non-small cell lung cancer (NSCLC). Central location and size greater than 3 cm are amongst indications for pre-operative invasive mediastinal staging but the quality of the evidence behind this recommendation is low.

Methods

We retrospectively reviewed all cases of cT2-4N0M0 NSCLCL after CT and TEP-CT which underwent surgical resection with lymph node dissection or had a positive invasive pre-operative mediastinal staging in our institution from 2014 to 2018.

Results

Three hundred and ten patients met inclusion criteria, 79 (25.5%) central and 231 (74.5%) peripheral tumors. Central tumor location was associated with a higher prevalence of pN2-3 disease (17.7% vs. 6.1%, P<0.001).

SUBMITTER: Guinde J 

PROVIDER: S-EPMC7797819 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature