Bioevaluation and molecular docking analysis of novel phenylpropanoid derivatives as potent food preservative and anti-microbials.

ABSTRACT: Novel derivatives were synthesized using natural scaffold, like phenylpropanoids C₆-C₃ backbone to reduce unfavorable browning of food due to tyrosinase and oxidative spoilage. Most of the compounds displayed mushroom tyrosinase inhibition better than kojic acid. Compound CE48 exhibited better anti-tyrosinase (IC₅₀-29.64 μM) and antioxidant (EC₅₀-12.67 μM) activity than the reference compounds, kojic acid (IC₅₀-50.30 μM) and ascorbic acid (EC₅₀-14.55 μM), respectively. Compounds SAM30, SE78, 11F, and CE48 showed better anti-B. subtilis, anti-S. aureus, and anti-A. niger activity, respectively, compared to their parents. Molecular docking studies between inhibitors and mushroom tyrosinase corroborated the

SUBMITTER: Neelam 

PROVIDER: S-EPMC7806689 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature