Total Synthesis of Marine Alkaloids Motuporamines A and B via Ring Expansion of Cyclic ?-Keto Esters.

ABSTRACT: An expedient total synthesis of the title marine sponge alkaloids has been developed. The salient features of the synthesis are as follows: (i) preparation of the required 13- and 14-membered cyclic lactams with n + 4 ring-expansion strategy of cyclic ?-keto esters and (ii) functional group manipulation of the resulted keto ester lactams. This approach used easily accessible and inexpensive materials/reagents, thus providing a promising alternative to the existing preparations.

SUBMITTER: Song ZJ 

PROVIDER: S-EPMC7808158 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature