Aspirin Use and Risk of Colorectal Cancer Among Older Adults.

ABSTRACT:

Importance

Although aspirin is recommended for the prevention of colorectal cancer (CRC) among adults aged 50 to 59 years, recent data from a randomized clinical trial suggest a lack of benefit and even possible harm among older adults.

Objective

To examine the association between aspirin use and the risk of incident CRC among older adults.

Design, setting, and participants

A pooled analysis was conducted of 2 large US cohort studies, the Nurses' Health Study (June 1, 1980-June 30, 2014) and Health Professionals Follow-up Study (January 1, 1986-January 31, 2014). A total of 94 540 participants aged 70 years or older were included and followed up to June 30, 2014, for women or January 31, 2014, for men. Participants with a diagnosis of any cancer, except nonmelanoma sk

SUBMITTER: Guo CG 

PROVIDER: S-EPMC7821085 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature