Western diet-induced increase in colonic bile acids compromises epithelial barrier in nonalcoholic steatohepatitis.

ABSTRACT: There is compelling evidence implicating intestinal permeability in the pathogenesis of nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain poorly understood. Here we examined the role of bile acids (BA) in western diet (WD)-induced loss of colonic epithelial barrier (CEB) function in mice with a genetic impairment in intestinal epithelial barrier function, junctional adhesion molecule A knockout mice, F11r^-/- . WD-fed knockout mice developed severe NASH, which was associated with increased BA concentration in the cecum and loss of CEB function. Analysis of cecal BA composition revealed selective increases in primary unconjugated BAs in the WD-fed mice, which correlated with increased abundance of microbial taxa linked to BA metabolism. In vitro permeabilit

SUBMITTER: Gupta B 

PROVIDER: S-EPMC7831197 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature