Ontology highlight
ABSTRACT:
SUBMITTER: Gupta B
PROVIDER: S-EPMC7831197 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Gupta Biki B Liu Yunshan Y Chopyk Daniel M DM Rai Ravi P RP Desai Chirayu C Kumar Pradeep P Farris Alton B AB Nusrat Asma A Parkos Charles A CA Anania Frank A FA Raeman Reben R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20200410 5
There is compelling evidence implicating intestinal permeability in the pathogenesis of nonalcoholic steatohepatitis (NASH), but the underlying mechanisms remain poorly understood. Here we examined the role of bile acids (BA) in western diet (WD)-induced loss of colonic epithelial barrier (CEB) function in mice with a genetic impairment in intestinal epithelial barrier function, junctional adhesion molecule A knockout mice, F11r<sup>-/-</sup> . WD-fed knockout mice developed severe NASH, which w ...[more]