Association of common genetic variants with brain microbleeds: A genome-wide association study.

ABSTRACT:

Objective

To identify common genetic variants associated with the presence of brain microbleeds (BMBs).

Methods

We performed genome-wide association studies in 11 population-based cohort studies and 3 case-control or case-only stroke cohorts. Genotypes were imputed to the Haplotype Reference Consortium or 1000 Genomes reference panel. BMBs were rated on susceptibility-weighted or T2*-weighted gradient echo MRI sequences, and further classified as lobar or mixed (including strictly deep and infratentorial, possibly with lobar BMB). In a subset, we assessed the effects of APOE ε2 and ε4 alleles on BMB counts. We also related previously identified cerebral small vessel disease variants to BMBs.

Results

BMBs were detected in 3,556 of the 25,862 participants, of whi

SUBMITTER: Knol MJ 

PROVIDER: S-EPMC7836652 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature