Artificial selection for host resistance to tumour growth and subsequent cancer cell adaptations: an evolutionary arms race.

ABSTRACT:

Background

Cancer progression is governed by evolutionary dynamics in both the tumour population and its host. Since cancers die with the host, each new population of cancer cells must reinvent strategies to overcome the host's heritable defences. In contrast, host species evolve defence strategies over generations if tumour development limits procreation.

Methods

We investigate this "evolutionary arms race" through intentional breeding of immunodeficient SCID and immunocompetent Black/6 mice to evolve increased tumour suppression. Over 10 generations, we injected Lewis lung mouse carcinoma cells [LL/2-Luc-M38] and selectively bred the two individuals with the slowest tumour growth at day 11. Their male progeny were hosts in the subsequent round.

Results

The evolved S

SUBMITTER: Ibrahim-Hashim A 

PROVIDER: S-EPMC7852689 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature