Novel controlled and targeted releasing hydrogen sulfide system exerts combinational cerebral and myocardial protection after cardiac arrest.

ABSTRACT:

Background

Cardiac arrest (CA) is a leading cause of death worldwide. Even after successful cardiopulmonary resuscitation (CPR), the majorities of survivals are companied with permanent myocardial and cerebral injury. Hydrogen sulfide (H₂S) has been recognized as a novel gasotransmitter exerting multiple organ protection; however, the lacks of ideal H₂S donors which can controlled release H₂S to targeted organs such as heart and brain limits its application.

Results

This work utilized mesoporous iron oxide nanoparticle (MION) as the carriers of diallyl trisulfide (DATS), with polyethylene glycol (PEG) and lactoferrin (LF) modified to MIONs to acquire the prolonged circulation time and brain-targeting effects, and a novel targeted H₂

SUBMITTER: Sun X 

PROVIDER: S-EPMC7866762 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature