Acne Vulgaris is Associated with the Human β-Defensin 1-Gene Polymorphisms in Han Chinese Ethnic Group Patients.

ABSTRACT:

Objective

To study the relationship between the single nucleotide polymorphisms (SNPs) of the human β-defensin 1-gene (DEFB1) and the genetic susceptibility of acne vulgaris in the Han Chinese ethnic group.

Methods

A total of 104 patients with acne vulgaris and 126 healthy participants were included in our study. We analyzed the association between acne vulgaris and the polymorphisms in the DEFB1 G-52A, C-44G, and G-20A gene. We then analyzed the relationship between the different genotypes and the susceptibility to acne vulgaris.

Results

The frequency of DEFB1 C-44G genetic polymorphisms between the acne vulgaris group and the control group was significantly different (P < 0.05). The frequency of DEFB1 G-20A genetic polymorphisms between the acne vulgaris group and t

SUBMITTER: Tian LM 

PROVIDER: S-EPMC7869712 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature