Cerebellar Neuromodulation for Stroke.
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ABSTRACT: Purpose of review
This paper reviews the current preclinical and clinical evidence for cerebellar deep brain stimulation for stroke rehabilitation.Recent findings
We have demonstrated the effectiveness of cerebellar stimulation for stroke rehabilitation in rodent models, which has been reproduced by other groups. Synaptogenesis, neurogenesis, and vicariation of function in the perilesional cortex likely contribute to the mechanistic underpinnings of the effectiveness of this therapy. A Phase I clinical trial investigating dentate nucleus stimulation for improvement of hemiparesis due to stroke is currently underway, and results thus far are encouraging.Summary
Activation of the rodent cerebellar dentate nucleus promotes functional motor recovery following stroke. Although results of a Phase I clinical trial are pending, substantial preclinical evidence indicates that deep brain stimulation of the dentate nucleus is a promising therapeutic modality.
SUBMITTER: Cooperrider J
PROVIDER: S-EPMC7879492 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Cerebellar Neuromodulation for Stroke.
Cooperrider Jessica J Momin Arbaz A Baker Kenneth B KB Machado Andre G AG
Current physical medicine and rehabilitation reports 20200220 2
<h4>Purpose of review</h4>This paper reviews the current preclinical and clinical evidence for cerebellar deep brain stimulation for stroke rehabilitation.<h4>Recent findings</h4>We have demonstrated the effectiveness of cerebellar stimulation for stroke rehabilitation in rodent models, which has been reproduced by other groups. Synaptogenesis, neurogenesis, and vicariation of function in the perilesional cortex likely contribute to the mechanistic underpinnings of the effectiveness of this ther ...[more]
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