Cerebellar Neuromodulation for Stroke.

ABSTRACT:

Purpose of review

This paper reviews the current preclinical and clinical evidence for cerebellar deep brain stimulation for stroke rehabilitation.

Recent findings

We have demonstrated the effectiveness of cerebellar stimulation for stroke rehabilitation in rodent models, which has been reproduced by other groups. Synaptogenesis, neurogenesis, and vicariation of function in the perilesional cortex likely contribute to the mechanistic underpinnings of the effectiveness of this therapy. A Phase I clinical trial investigating dentate nucleus stimulation for improvement of hemiparesis due to stroke is currently underway, and results thus far are encouraging.

Summary

Activation of the rodent cerebellar dentate nucleus promotes functional motor recovery following stroke. Al

SUBMITTER: Cooperrider J 

PROVIDER: S-EPMC7879492 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature