Associations of Serum Calciprotein Particle Size and Transformation Time With Arterial Calcification, Arterial Stiffness, and Mortality in Incident Hemodialysis Patients.

ABSTRACT:

Rationale & objective

Characteristics of the transformation of primary to secondary calciprotein particles (CPPs) in serum, including the size of secondary CPP (CPP2) aggregates and the time of transformation (T₅₀), may be markers for arterial calcification in patients undergoing hemodialysis (HD). We examined the associations of CPP2 aggregate size and T₅₀ with arterial calcification in incident HD patients.

Study design

Prospective cohort study.

Setting & participants

Incident HD patients (n=402with available CPP2 measures and n=388with available T₅₀ measures) from the Predictors of Arrhythmic and Cardiovascular Risk in End-Stage Renal Disease (PACE) Study PREDICTORS: Serum CPP2 size and T₅₀ at baseline.

Outcomes

Pr

SUBMITTER: Chen W 

PROVIDER: S-EPMC7881044 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature