Correlates of protection against SARS-CoV-2 in rhesus macaques.

ABSTRACT: Recent studies have reported the protective efficacy of both natural¹ and vaccine-induced^2-7 immunity against challenge with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in rhesus macaques. However, the importance of humoral and cellular immunity for protection against infection with SARS-CoV-2 remains to be determined. Here we show that the adoptive transfer of purified IgG from convalescent rhesus macaques (Macaca mulatta) protects naive recipient macaques against challenge with SARS-CoV-2 in a dose-dependent fashion. Depletion of CD8⁺ T cells in convalescent macaques partially abrogated the protective efficacy of natural immunity against rechallenge with SARS-CoV-2, which suggests a role for cellular immunity in the context of waning or s

SUBMITTER: McMahan K 

PROVIDER: S-EPMC7906955 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature