Genetic Scores of eNOS, ACE and VEGFA Genes Are Predictive of Endothelial Dysfunction Associated Osteoporosis in Postmenopausal Women.

ABSTRACT: The present study aimed to examine the participation and contribution of endothelial nitric oxide synthase (eNOS), angiotensin converting enzyme (ACE) and vascular endothelial growth factor (VEGFA) genes for the risk of endothelial dysfunction (ED)-associated osteoporosis risk in postmenopausal women of Punjab, India. Women with ED were categorized into women with osteoporosis (n = 346) and women without osteoporosis (n = 330). They were examined for selected SNPs within eNOS, ACE and VEGFA genes. Linear regression analysis revealed a positive association of ED with bone mineral densities (BMDs) at femoral neck (r² = 0.78, p < 0.001) and lumbar spine (r² = 0.24, p = 0.001) after Bonferroni correction. Three susceptibili

SUBMITTER: Singh P 

PROVIDER: S-EPMC7908366 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature