ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking.
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ABSTRACT:
SUBMITTER: Xie MX
PROVIDER: S-EPMC7930092 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking.
Xie Man-Xiu MX Cao Xian-Ying XY Zeng Wei-An WA Lai Ren-Chun RC Guo Lan L Wang Jun-Chao JC Xiao Yi-Bin YB Zhang Xi X Chen Di D Liu Xian-Guo XG Zhang Xiao-Long XL
Nature communications 20210303 1
Effective treatments for patients suffering from heat hypersensitivity are lacking, mostly due to our limited understanding of the pathogenic mechanisms underlying this disorder. In the nervous system, activating transcription factor 4 (ATF4) is involved in the regulation of synaptic plasticity and memory formation. Here, we show that ATF4 plays an important role in heat nociception. Indeed, loss of ATF4 in mouse dorsal root ganglion (DRG) neurons selectively impairs heat sensitivity. Mechanisti ...[more]
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