Metabolomic and elemental profiling of human tissue in kidney cancer.

ABSTRACT:

Introduction

Kidney cancer is one of the most frequently diagnosed and the most lethal urinary cancer. Despite advances in treatment, no specific biomarker is currently in use to guide therapeutic interventions.

Objectives

Major aim of this work was to perform metabolomic and elemental profiling of human kidney cancer and normal tissue and to evaluate cancer biomarkers.

Methods

Metabolic and elemental profiling of tumor and adjacent normal human kidney tissue from 50 patients with kidney cancer was undertaken using three different analytical methods.

Results

Five potential tissue biomarkers of kidney cancer were identified and quantified using with high-resolution nuclear magnetic resonance spectroscopy. The contents of selected chemical elements in tissues was

SUBMITTER: Niziol J 

PROVIDER: S-EPMC7932981 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature