Genome-wide epistasis analysis for Alzheimer's disease and implications for genetic risk prediction.

ABSTRACT:

Background

Single-nucleotide polymorphisms (SNPs) identified by genome-wide association studies only explain part of the heritability of Alzheimer's disease (AD). Epistasis has been considered as one of the main causes of "missing heritability" in AD.

Methods

We performed genome-wide epistasis screening (N = 10,389) for the clinical diagnosis of AD using three popularly adopted methods. Subsequent analyses were performed to eliminate spurious associations caused by possible confounding factors. Then, candidate genetic interactions were examined for their co-expression in the brains of AD patients and analyzed for their association with intermediate AD phenotypes. Moreover, a new approach was developed to compile the epistasis risk factors into an epistasis risk score (ERS) b

SUBMITTER: Wang H 

PROVIDER: S-EPMC7934265 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature