Squamous cell carcinoma of the head and neck with unknown primary: trends and outcomes from a hospital-based registry.

ABSTRACT:

Background

Squamous cell carcinoma of unknown primary of the head and neck region is a known entity described mainly by retrospective reports. We searched a hospital-based registry to better describe the changing incidence, and to assess diagnostic and treatment strategies.

Methods

The National Comprehensive Cancer Database was queried for head and neck cancers from oropharynx, tonsil, tongue, larynx, hypopharynx primary sites with a designation of clinical T0, representing an unknown primary. Kaplan Meier, Cox multivariate models, and propensity matched cohorts were used to assess significant factors for overall survival.

Results

There were 964 cases that met the criteria, and 468 cases with known treatments, staging, and survival data. The incidence increased over t

SUBMITTER: Cummings MA 

PROVIDER: S-EPMC7944267 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature