Depression Risk Is Associated With Weakened Synchrony Between the Amygdala and Experienced Emotion.

ABSTRACT:

Background

Major depressive disorder (MDD) is associated with aberrant limbic neural responses to emotional stimuli. We assessed how self-generated emotions modulate trial-by-trial limbic activity and whether this brain-emotion synchrony varies by familial MDD risk (regardless of personal MDD history) and neuroticism.

Methods

Participants (n = 74, mean age = 34 years) were later-generation family members of depressed or nondepressed probands as part of a longitudinal cohort study. Using an emotion induction task, we examined participant-specific modulation of anatomically defined limbic neurobiology. Neuroticism, mental health, and familial parenting style were assessed, and MDD assessments were routinely collected throughout the previous longitudinal assessments of the stud

SUBMITTER: Tottenham N 

PROVIDER: S-EPMC7946704 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature