In vitro Antibacterial Activity of an FDA-Approved H⁺-ATPase Inhibitor, Bedaquiline, Against Streptococcus mutans in Acidic Milieus.

ABSTRACT:

Background

Dental caries is an acid-related disease. Current anti-caries agents mainly focus on the bacteriostatic effect in a neutral environment and do not target acid-resistant microorganisms related to caries in acidic milieus.

Objectives

To assess the in vitro antibacterial activities of bedaquiline against oral pathogens in acidic milieus.

Methods

Streptococcus mutans, Streptococcus sanguinis, and Streptococcus salivarius were used to prepare the mono-/multiple suspension and biofilm. The MIC and IC₅₀ of bedaquiline against S. mutans were determined by the broth microdilution method. Bedaquiline was compared regarding (i) the inhibitory activity in pH 4-7 and at different time points against planktonic and biofilm; (

SUBMITTER: Zhang M 

PROVIDER: S-EPMC7947916 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature