Blockade of High-Fat Diet Proteomic Phenotypes Using Exercise as Prevention or Treatment.

ABSTRACT: The increasing consumption of high-fat foods combined with a lack of exercise is a major contributor to the burden of obesity in humans. Aerobic exercise such as running is known to provide metabolic benefits, but how the overconsumption of a high-fat diet (HFD) and exercise interact is not well characterized at the molecular level. Here, we examined the plasma proteome in mice for the effects of aerobic exercise as both a treatment and as a preventative regimen for animals on either a HFD or a healthy control diet. This analysis detected large changes in the plasma proteome induced by the HFD, such as increased abundance of SERPINA7, ALDOB, and downregulation of SERPINA1E and complement factor D (CFD; adipsin). Some of these changes were significantly reverted using exercise as a preventa

SUBMITTER: Martinez-Huenchullan SF 

PROVIDER: S-EPMC7950115 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature