CD4⁺ T Cell-Specific Proteomic Pathways Identified in Progression of Hypertension Across Postmenopausal Transition.

ABSTRACT: Background Menopause is associated with an increase in the prevalence and severity of hypertension in women. Although premenopausal females are protected against T cell-dependent immune activation and development of angiotensin II (Ang II) hypertension, this protection is lost in postmenopausal females. Therefore, the current study hypothesized that specific CD4⁺ T cell pathways are regulated by sex hormones and Ang II to mediate progression from premenopausal protection to postmenopausal hypertension. Methods and Results Menopause was induced in C57BL/6 mice via repeated 4-vinylcyclohexene diepoxide injections, while premenopausal females received sesame oil vehicle. A subset of premenopausal mice and all menopausal mice were infused with Ang II for 14 days (Control, Ang II, Me

SUBMITTER: Uhlorn JA 

PROVIDER: S-EPMC7955317 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature