Compositional and Functional Changes in the Gut Microbiota in Irritable Bowel Syndrome Patients.

ABSTRACT:

Background/aims

This study aimed to characterize the changes in the gut microbiota of irritable bowel syndrome (IBS) patients and to investigate the consequent alterations in bacterial functions.

Methods

We performed 16S rRNA metagenomic sequencing and a phylogenetic investigation of communities by reconstruction of unobserved states (PICRUSt) analyses using fecal samples from control (n=12) and diarrhea-dominant IBS patients (n=7).

Results

The samples were clustered by the principal coordinates analysis depending on the presence of IBS (p=0.003). In the IBS patients, the abundances of Acidaminococcaceae, Sutterellaceae, and Desulfovibrionaceae were significantly increased, while those of Enterococcaceae, Leuconostocaceae, Clostridiaceae, Peptostreptococcaceae, and La

SUBMITTER: Lee SM 

PROVIDER: S-EPMC7960967 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature