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Enantioselective Synthesis of a New Non-Natural Gabosine.

ABSTRACT: The preparation of a new non-natural gabosine is reported, in which the chirality is transferred from the toluene's biotransformed metabolite (1R,2S)-3-methylcyclohexa-3.5-diene-1,2-diol. Further chemical transformations to introduce additional functionality and chirality to the molecule were also accomplished.

SUBMITTER: Colobbio M

PROVIDER: S-EPMC7961443 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Enantioselective Synthesis of a New Non-Natural Gabosine.

Colobbio Maximiliano M Pandolfi Enrique E Schapiro Valeria V

Molecules (Basel, Switzerland) 20210306 5

The preparation of a new non-natural gabosine is reported, in which the chirality is transferred from the toluene's biotransformed metabolite (1R,2S)-3-methylcyclohexa-3.5-diene-1,2-diol. Further chemical transformations to introduce additional functionality and chirality to the molecule were also accomplished. ...[more]

PMID: 33800731

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